Synthesis and characterization of a new fluorescent probe for reactive oxygen species.
نویسندگان
چکیده
We report the development of a new fluorescence sensor for reactive oxygen species (ROS) based on a benzofurazan structure. The sensor, NBFhd, is initially non-fluorescent and reacts with peroxyl radicals by hydrogen transfer in an aqueous medium under neutral conditions to release the fluorescent N-methyl-4-amino-7-nitrobenzofurazan (NBF) and 1,4-benzoquinone. NBFhd shows excellent contrast and no interference in the region of cell autofluorescence and is a new tool to detect ROS in homogeneous and biological systems.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 9 شماره
صفحات -
تاریخ انتشار 2007